Science & Research

Clinical Studies

TESTED BY ATHLETES. PROVEN BY SCIENCE.

Levagen^® and Levagen^®+ are the only branded palmitoylethanolamides in the industry with gold-standard clinical studies. Tested on various populations, Levagen^® and Levagen^®+ are clinically proven to:

Reduce Discomfort

Reduce joint strain and stiffness

Delay fatigue,
Reduce muscle damage,
Stimulate muscle growth,
Improve recovery

Restful Sleep

Reduce anxiety

Support cognitive fucntion and BDNF production

Reduce skin inflammation and redness

Levagen®+ vs Standard PEA

Levagen^®+ demonstrated 1.75% greater increase in levels of PEA in the body compared to standard PEA. Rapid absorption and action was seen with levels peaking 45 minutes post-ingestion.

Rao, Amanda, Alistair Mallard and David Briskey. "Increased absorption of Palmitoylethanolamide using a Novel Dispersion Technology System (LipiSperse^®)" Journal of Nutraceuticals and Food Science (2019)

Supporting Joint Health with Levagen®+

Joint pain affects various individuals, whether an active senior or elite athlete, which leads to decreased quality of life, reduced performance and immobility.

Levagen^® has been proven to improve symptoms of joint discomfort, stiffness and function dose-dependently over the course of 8 weeks.

Palmitoylethanolamide is both a powerful anti-inflammatory and pain reliever, providing an all-in-one solution for managing discomfort.

Steels, Elizabeth. et al. "A double-blind" randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis." Inflammopharmacology 27.3 (2019): 475 - 485

Relax with Levagen®

Work, family and environment can take its toll at times and the need to relax is of vital importance when wanting to cope with day-to-day stressors.

Supplementing with Levagen^® has been found to significantly reduce levels of anxiety and increase quality of life within 14 days.

PEA helps improve mood through its ability to influence the endocannabinoid system, which is known to have an influence on mood and sleep.

Rao, Amanda. et al. "Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interregional study." Sleep Science and Practice 12.5 (2021)

Enhance Sports Performance with Levagen®+

Pushing past your limits is necessary when wanting to adapt and beat your competition. Levagen^®+ helps you push past your threshold by reducing lactic acid build up and decreasing fatigue.

Clinical studies have also found Levagen^®+ to reduce muscle damage and stimulate growth of muscle tissue post-exercise, allowing individuals to reduce recovery time and enhance muscle adaptations.

Mallard, Briskey, Richards, Mills & Rao "The Effect of Orally Dosed Levagen+ (palmitoylethanolamide) on Exercise Recovery in Healthy Males - A Double-Blind, Randomized, Placebo-Controlled Study". Nutrients 12.3 (2020):596

Migraine Study

Figure 2. (A) Total VAS score over the first 4 h and (B) change in VAS score over the first 4 h. a= significant difference from the baseline in the Levagen^®+ group (p < 0.05); b = significant difference from the baseline in the placebo group (p < 0.05); *=significant difference between groups (p < 0.05).

Levagen^®+ was clinically researched to significantly reduce VAS scores and resolved migraines classified as moderate when compared to placebo.

Briskey D, Skinner R, Smith C, Rao A. Effectiveness of Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy Participants-A Double-Blind Randomised Controlled Study. Pharmaceuticals (Basel).

Cognitive Function Study

In a brand new study, Levagen^®+ efficacy was studied at 700mg or a matching placebo for 6 weeks in a double armed, cross-over trail.

Levagen^®+ supported significant improvement in serum BDNF levels when compared to placebo and helped to improve memory through better first success and fewer errors.

Kim N, Parolin B, Renshaw D, Deb SK, Zariwala MG. Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial. Nutrients. 2024.

Skin Health Study

The recently published topical study showed the efficacy of Levagen^®+ in a topical formulation applied twice daily for 4 weeks.

Levagen^®+ supported a significant reduction in skin dryness, skin redness, and reduced a total POEM score compared to a comparator cream.

Rao A, Moussa AA, Erickson J, Briskey D. Efficacy of Topical Palmitoylethanolamide (Levagen+) for the Management of Eczema Symptoms: A Double-Blind, Comparator-Controlled, Randomized Clinical Trial. Skin Pharmacol Physiol. 2023

How does it work?

PEA operates through multiple pathways and mechanisms within the body to provide its beneficial effects:

‍Directly
‍PEA reduces inflammation locally by binding on to PPAR-a receptors and inhibiting secretion of pro-inflammatory signalling molecules.

PEA enhances the levels and actions of other compounds that are anti-inflammatory and provide pain relief (1, 2). This mechanism is known as the 'entourage effect'. PEA has a naturally low affinity for CB1 and CB2 receptors and only activates transient receptor potential vanilloid type-1 (TRPV1) channels when at very high concentrations in the body. TRPV1 channels are found on the outside of nerve cells and play a part in pain and temperature regulation (3).

‍Indirectly
‍To exert its beneficial effects. PEA can enhance the levels and actions of another endocannabinoid, anandamide, which is often dubbed as the 'bliss' molecule or the body's own natural THC (the compound in cannabis that has psychoactive effects and produces a 'high'). Anandamide has a profound analgesic response, before the pain signal even arrives at the spinal cord. The mode of action that PEA acts upon is by inhibiting the enzyme that degrades this molecule - Fatty Acid Amide Hydrolaze (FAAH). Anandamide act upon CB1 and CB2 receptors and TRPV1 channels, helping to combat pain and increase relaxation (4, 5, 6).

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This material is educational in nature and is not intended to serve as regulatory and/or legal advice.

Not all claims made are valid in all global regions.

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